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. 2018 Dec 20;9:1469. doi: 10.3389/fphar.2018.01469

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Copyright © 2018 Mao, Yi, Wang, Huang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of cos on liver histology in mice. (I) The histopathological changes of liver. (I-A) Control, (I-B) LPS/D-GalN (LPS 50 μg/kg; D-GalN: 400 mg/kg; arrow 1: central venous hyperemia; arrow 2: inflammatory infiltration), (I-C) LPS/D-GalN + L-cos (I-B + cos 20 mg/kg), (I-D) LPS/D-GalN + H-cos (I-B + cos 40 mg/kg), (I-E) LPS/D-GalN + sily (I-B + cos 40 mg/kg) (magnification: 200×). (II) The scores of the liver injury in the mice after treated with cos. The data represented as mean ± SD (n = 10). ^∗∗P < 0.01 vs. Control group; ^#P < 0.05, ^##P < 0.01 vs. LPS/D-GalN group.