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. 2018 Dec 24;11:201–215. doi: 10.2147/CMAR.S190694

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© 2019 Tang et al. This work is published and licensed by Dove Medical Press Limited

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Knockdown of MARCH5 suppressed breast cancer growth and metastasis in vivo.

Notes: (A) Growth of subcutaneous xenografts established from MDA-MB-231 cells with stable MARCH5 knockdown or control cells. shMARCH5, shRNA expression vector against MARCH5; shCtrl, control shRNA. (B) The weight of tumors dissected from mice was compared between the shMARCH5 and shCtrl groups. (C and D) The expression levels of MARCH5 and Ki-67 were detected by IHC analysis in the two groups of subcutaneous xenografts tumors. Scale bars, 10 µm. (E) Representative images and numbers of lung metastatic foci in each group are shown. Scale bars, 10 µm. *P<0.05.