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(A) The PTX, NPPA-PTX, and dissociated PTX from NPPA-PTX levels (µM) in tumor tissues after a single intravenous administration of NPPA-PTX@PEG NPs at a dose of 18.11 mg/kg (equimolar to 15 mg/kg PTX) or (B) Taxol at a dose of 15 mg/kg to MDA-MB-231 tumor-bearing nude mice. (Means ± SD, n=3).
Abbreviations: NPPA, 3-(2-Nitrophenyl) propionic acid; PTX, paclitaxel.
