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. 2018 Dec 27;24(2):021207. doi: 10.1117/1.JBO.24.2.021207

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© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Fig. 8 — The ratio of neoplastic-to-normal colon average abundance values for each patient for elastin and NADH. The ratio was computed as (neoplastic abundance/normal colon abundance). Collagen, FAD, and PPIX ratios were not meaningful due to near 0 signal in most unmixed images. (a) The ratio of neoplastic-to-normal colon signal for elastin was $< 1$ for 8 of the 9 patients, indicating more fluorescence due to elastin in normal colon specimens than neoplastic specimens. (b) The ratio of neoplastic-to-normal colon signal for NADH was $> 1$ for 6 of the 9 patients, indicating less fluorescence due to NADH in normal colon specimens than neoplastic specimens. (c) The ratio of residual fluorescence unable to be accounted for by the spectral library <1 for 7 of 9 patients, indicating a more encompassing unmixing for the neoplastic specimens than the normal colon specimens.