Table 2.
Literature validation of nodes in top 5% dysregulated FFLs associated with cardiac development and cardiovascular disorders
| Type | Molecule | Known research | Year | PMID |
|---|---|---|---|---|
| miRNA | hsa‐let‐7c‐5p | (1) Cardiac development | (1) 2017 | (1) 29057256 |
| (2) Cardiac development | (2) 2014 | (2) 24365598 | ||
| (3) Heart failure | (3) 2016 | (3) 27072074 | ||
| miRNA | hsa‐miR‐124‐3p | (1) Cardiomyocyte hypertrophy | (1) 2017 | (1) 28478799 |
| (2) Vascular smooth muscle cells proliferation and migration | (2) 2017 | (2) 29042195 | ||
| (3) Atherosclerosis | (3) 2017 | (3) 28457624 | ||
| miRNA | hsa‐miR‐138‐5p | (1) Congenital Heart Disease | (1) 2018 | (1) 29298094 |
| (2) Alcoholic cardiomyopathy | (2) 2015 | (2) 25791397 | ||
| (3) Cardiac development | (3) 2008 | (3) 19004786 | ||
| miRNA | hsa‐miR‐140‐5p | (1) Cardiac development | (1) 2015 | (1) 26465880 |
| (2) Heart failure | (2) 2016 | (2) 27072074 | ||
| (3) Cardiotoxicity | (3) 2017 | (3) 29304479 | ||
| miRNA | hsa‐miR‐143‐3p | (1) Dilated cardiomyopathy | (1) 2018 | (1) 29335596 |
| (2) Insulin action in cardiomyocytes | (2) 2013 | (2) 23812417 | ||
| (3) Coronary heart disease | (3) 2017 | (3) 29321799 | ||
| miRNA | hsa‐miR‐155‐5p | (1) Cardiac hypertrophy | (1) 2015 | (1) 26086795 |
| (2) Dilated cardiomyopathy | (2) 2015 | (2) 25840506 | ||
| miRNA | hsa‐miR‐197‐3p | (1) Cardiometabolic | (1) 2017 | (1) 28178938 |
| (2) Cardiovascular death | (2) 2015 | (2) 26720041 | ||
| miRNA | hsa‐miR‐338‐3p | (1)Diabetic cardiomyopathy | (1) 2014 | (1) 23797610 |
| (2) Autophagy in cardiomyocytes | (2) 2017 | (2) 29247537 | ||
| miRNA | hsa‐miR‐493‐5p | (1) Coronary microembolisation | (1) 2017 | (1) 28968594 |
| Gene | ACTG1 | (1) Myocardial injury | (1) 2018 | (1) 29068691 |
| Gene | ALOX5AP | (1) Familial hypercholesterolemia | (1) 2009 | (1) 19361804 |
| (2) Coronary heart disease | (2) 2010 | (2) 21199733 | ||
| Gene | BCL2L1 | (1) Cardiac dysfunction | (1) 2008 | (1) 18313710 |
| Gene | CCL2 | (1) Cardiomyopathy | (1) 2014 | (1) 24980781 |
| (2) Ischaemic cardiomyopathy | (2) 2007 | (2) 17692033 | ||
| (3) Cardiac fibrosis | (3) 2009 | (3) 19482709 | ||
| Gene | DLC1 | (1) Congenital heart disease | (1) 2014 | (1) 24587289 |
| Gene | ERRFI1 | (1) Metabolic syndrome | (1) 2016 | (1) 27778020 |
| Gene | MCL1 | (1) Survival of cardimyocytes during oxidative stress | (1) 2016 | (1) 27220418 |
| (2) Myocardial homoeostasis and autophagy | (1) 2013 | (1) 24165322 | ||
| Gene | MT2A | (1) Cardiomyopathy | (1) 2016 | (1) 27477335 |
| (2) Coronary heart disease | (1) 2014 | (2) 25555862 | ||
| Gene | NDUFA2 | (1) Cardiomyocytes oxidative stress | (2) 2013 | (1) 23891692 |
| Gene | SERPINE1 | (1) Hypertrophic cardiomyopathy | (1) 2013 | (1) 23756156 |
| (2) Heart failure | (2) 2016 | (2) 27284354 | ||
| Gene | TNFRSF10B | (1) Plasma fatty acid distribution | (1) 2010 | (1) 20410100 |
| TF | CEBPB | (1) Cardiovascular disease | (1) 2010 | (1) 20460359 |
| (2) Cardiac fibroblast senescence | (2) 2015 | (2) 25472717 | ||
| TF | CEBPD | (1) Ischaemic cardiomyopathy | (1) 2015 | (1) 25884818 |
| TF | E2F4 | (1) Cardiomyocyte proliferation | (1) 2010 | (1) 19955219 |
| (2) Cardiomyoycte cell proliferation | (2) 2006 | (2) 17102628 | ||
| TF | KLF6 | (1) Cardiac fibrosis | (1) 2015 | (1) 25987545 |
| (2) Cardiac fibrosis | (2) 2013 | (2) 23724005 | ||
| TF | STAT3 | (1) Cardiac Hypertrophy and Fatty Heart | (1) 2015 | (1) 26161779 |
| (2) Familial hypertrophic cardiomyopathy | (2) 2008 | (2) 18362229 | ||
| (3) Cardiomyocyte apoptosis | (3) 2014 | (3) 25200830 |