Figure 7.

FG‐4592 increases level of HIF‐1α and regulates apoptosis‐related proteins in AHH‐1. The effects of FG‐4592 on HIF1‐α were detected using Western Blot. Level of HIF‐1α was measured at different time points after the treatment of FG‐4592 (A). Cell lysate was obtained at 6 h after irradiation and used to evaluate the regulation of FG‐4592 on apoptosis‐related molecules. Apoptosis promoting molecules (c‐caspase3 and cyt‐c) are down‐regulated and molecules that inhibit apoptosis are up‐regulated by FG‐4592 after irradiation in AHH‐1 (B)