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. 2018 Nov 22;23(1):556–567. doi: 10.1111/jcmm.13960

Figure 4.

Figure 4

Modulation of angiogenesis by let‐7a and TGFBR3 in HUVECs. A, HUVECs transfected with let‐7a were subjected to tube‐like network formation in matrigel. After 6 h, tube‐like network formation was observed and photographed. B, The tube number was evaluated using Image J and let‐7a mimics group was normalized by the Con mimics (negative control) group, n = 3 (**P < 0.01). C, HUVECs transfected with siRNA were subjected to tube‐like network formation in matrigel. After 6 h, tube‐like network formation was observed and photographed. D, The tube number was evaluated using Image J and TGFBR3 siRNA group was normalized to the Con siRNA group, n = 3 (****P < 0.0001). E, HUVECs transfected with let‐7a mimics and co‐injection with let‐7a and TGFBR3 clone were subjected to tube‐like network formation in matrigel. After 6 h, tube‐like network formation was observed and photographed. F, The tube number was evaluated using Image J, let‐7a mimics group and let‐7a mimics+TGFBR3 clone was normalized to the Con mimics group, n = 3 (**P < 0.01, ***P < 0.001, ****P < 0.0001)