Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The model of miR‐520b regulating NSCLC tumourigenesis. (A) In normal lung cells, SPOP ubiquitinates GLI2/3, resulting in GLI2/3 degradation and Hh pathway suppression. Under this condition, Hh pathway activity keeps at the basal level. (B) In NSCLC cells, miR‐520b is up‐regulated and targets SPOP mRNA, removing SPOP‐mediated GLI2/3 destabilization. In turn, Hh pathway is hyperactivated
