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. 2018 Nov 23;23(1):641–655. doi: 10.1111/jcmm.13969

Figure 4.

Figure 4

Characteristic immunohistochemical staining of DVL1, DVL2, DVL3, TCF1 and LEF1 proteins in astrocytoma. A) astrocytic brain tumour grade I showing strong cytoplasmic and nuclear staining of DVL1, B) astrocytic brain tumour grade IV showing weak cytoplasmic staining of DVL1, C) astrocytic brain tumour grade I showing strong nuclear staining of DVL2, D) astrocytic brain tumour grade IV showing strong cytoplasmic staining of DVL2, E) astrocytic brain tumour grade I showing lack of expression of DVL3, F) astrocytic brain tumour grade IV showing strong membranous, cytoplasmic and nuclear staining of DVL3, G) astrocytic brain tumour grade I showing weak nuclear expression of TCF1, H) astrocytic brain tumour grade IV showing moderate and strong expression of TCF1, I) astrocytic brain tumour grade I showing weak nuclear expression of LEF1, J) astrocytic brain tumour grade IV showing moderate and strong nuclear expression of LEF1. Scale bar 50 μm