Table 2. Phenotypic similarities between nup88-/- zebrafish and FADS fetuses.
Danio rerio | FADS fetuses | Comments |
---|---|---|
Impaired locomotor behaviour | Progressive akinesia | |
Decreased head and eye size | Microcephaly | Not in all FADS cases examined |
Flat head without protruding mouth | Flat face | |
Lack of pharyngeal arches, dysmorphic jaw | Micrognathia | |
Curvature of the anterior-posterior axis | Multiple joint contractures, deformed limbs | |
Aplastic swim bladder | Pulmonary hypoplasia |