Skip to main content
. 2018 Dec 7;14(12):e1007806. doi: 10.1371/journal.pgen.1007806

Fig 9. Model for Scd6-stimulated translational repression via Dhh1 and mRNA decapping by Dcp1/Dcp2, perturbed by the Ccr4/Not complex.

Fig 9

(i) Closed-loop mRNP formation by mutual interactions of eIF4G with eIF4E bound to the mRNA cap and PABP bound to the poly(A) tail of mRNA, activating mRNA for translation initiation. (ii) Scd6 is recruited to the mRNA by binding to the C-terminus of eIF4G, but might also interact independently with the 3’UTR. (iii) Scd6 recruits Dhh1 and Dcp1/Dcp2 to form an inactive mRNP incapable of recruiting the 43S PIC complex near the 5’ end of the mRNA. (iv) Dcp1/Dcp2 decaps the mRNA, dissociating eIF4E, and exposing the 5’ end of the mRNA for subsequent exonucleolytic degradation (depicted as dotted line). (v) Recruitment of the Ccr4/Not complex to the mRNA interferes with Scd6-mediated translational repression and mRNA degradation.