Table 2. Age-Period-Cohort Analysis Results of Colorectal Cancer Mortality in Urban and Rural China, 2000–2015^a .

Effect	Urban			Rural
	Coefficient (95% CI)	P Valueb	Relative Risk	Coefficient (95% CI)	P Valueb	Relative Risk
Age
20–24	−2.69 (−5.3 to −0.02)	.05	1 [Reference]	−1.85 (−3.49 to −0.20)	.03	1 [Reference]
25–29	−1.52 (−2.81 to −0.24)	.02	3.19	−1.50 (−2.67 to −0.33)	.01	1.41
30–34	−1.08 (−2.12 to −0.05)	.04	4.95	−0.97 (−1.84 to 0.11)	.03	2.39
35–39	−0.92 (−1.83 to −0.02)	.05	5.82	−0.75 (−1.51 to 0.01)	.05	3.00
40–44	−0.67 (−1.45 to 0.10)	.09	7.48	−0.73 (−1.44 to −0.02)	.05	3.06
45–49	−0.31 (−0.96 to 0.34)	.36	10.79	−0.38 (−0.97 to 0.21)	.20	4.32
50–54	0.11 (−0.41 to 0.63)	.68	16.37	−0.10 (−0.59 to 0.39)	.68	5.72
55–59	0.25 (−0.16 to 0.67)	.23	18.90	0.21 (−0.18 to 0.61)	.29	7.84
60–64	0.75 (0.45 to 1.06)	<.001	31.09	0.59 (0.29 to 0.89)	<.001	11.46
65–69	1.03 (0.79 to 1.28)	<.001	41.10	0.89 (0.65 to 1.13)	<.001	15.48
70–74	1.37 (1.11 to 1.63)	<.001	57.65	1.25 (1.02 to 1.49)	<.001	22.17
75–79	1.69 (1.36 to 2.03)	<.001	79.48	1.58 (1.28 to 1.87)	<.001	30.69
80–84	1.99 (1.54 to 2.44)	<.001	107.16	1.76 (1.36 to 2.15)	<.001	36.70
Periodc
2000	−0.17 (−0.39 to 0.05)	.14	1 [Reference]	−0.21 (−0.42 to −0.01)	.04	1 [Reference]
2005	−0.15 (−0.27 to −0.04)	.01	1.01	−0.10 (−0.22 to 0.02)	.10	1.12
2010	0.14 (0.03 to 0.25)	.01	1.36	0 (−0.12 to 0.12)	.97	1.24
2015	0.18 (−0.03 to 0.40)	.10	1.42	0.31 (0.12 to 0.51)	.002	1.69
Cohort
1920–1924	0.89 (0.29 to 1.50)	.004	1 [Reference]	0.93 (0.37 to 1.49)	.001	1 [Reference]
1925–1929	0.94 (0.46 to 1.43)	<.001	1.05	0.72 (0.27 to 1.16)	.002	0.81
1930–1934	0.99 (0.60 to 1.37)	<.001	1.09	0.96 (0.60 to 1.32)	<.001	1.03
1935–1939	0.88 (0.55 to 1.21)	<.001	0.99	0.65 (0.34 to 0.96)	<.001	0.76
1940–1944	0.66 (0.32 to 1.00)	<.001	0.79	0.68 (0.37 to 0.99)	<.001	0.78
1945–1949	0.60 (0.20 to 0.99)	.003	0.74	0.58 (0.21 to 0.95)	.002	0.70
1950–1954	0.54 (0.06 to 1.03)	.03	0.70	0.56 (0.11 to 1.01)	.02	0.69
1955–1959	0.39 (−0.21 to 0.99)	.20	0.61	0.37 (−0.18 to 0.92)	.19	0.57
1960–1964	0.16 (−0.57 to 0.88)	.67	0.48	0.05 (−0.62 to 0.72)	.88	0.41
1965–1969	−0.04 (−0.87 to 0.79)	.93	0.39	0.16 (−0.57 to 0.89)	.68	0.46
1970–1974	−0.38 (−1.34 to 0.58)	.43	0.28	−0.15 (−0.97 to 0.67)	.72	0.34
1975–1979	−0.57 (−1.61 to 0.48)	.29	0.23	−0.60 (−1.54 to 0.35)	.22	0.22
1980–1984	−1.06 (−2.33 to 0.20)	.10	0.14	−0.85 (−1.89 to 0.18)	.11	0.17
1985–1989	−1.26 (−2.84 to 0.32)	.12	0.12	−0.85 (−2.06 to 0.36)	.17	0.17
1990–1994	−1.41 (−3.70 to 0.88)	.23	0.10	−1.19 (−3.04 to 0.66)	.21	0.12
1995–1999	−1.33 (−6.57 to 3.91)	.62	0.11	−2.01 (−6.38 to 2.36)	.37	0.05

Abbreviation: CI, confidence interval.

^a Data source: China Health Statistics Yearbook (15).

^b Determined by z test.

^c Data for 2000 were not available; thus, we used as a substitute the available data from the nearest year (2002).