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. 2018 Dec 17;7:e39393. doi: 10.7554/eLife.39393

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© 2018, Oswald et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 7. — DJ-1β is a redox signaling hub that coordinates structural synaptic plasticity at motoneuron synaptic input and output terminals. Activity-induced ROS oxidize DJ-1β, leading to PTEN inhibition and thus to a gain in PI3Kinase signaling, which regulates activity-induced NMJ elaboration of boutons and active zones. At higher activity/ROS thresholds additional, yet to be defined, pathways downstream of DJ-1β are activated, implementing adaptive reductions of active zones at the NMJ and dendritic arbor length in the CNS.