Fig. 5.

Transient activation of dnFGFR2b reveals critical periods for FGFR2b ligands in otic morphogenesis. (A-R) Paintfilled ears from control and experimental embryos with genotypes indicated above. DOX was provided to pregnant dams at E8.25 (A-D′), E8.75 (E-F′), E9.25 (G-J′), E9.75 (K-L′), E10.25 (M-P′) or E10.75 (Q,R) for the hours indicated above each panel. The number of ears from each treatment showing the same phenotype is indicated at the lower left. Alternate phenotypes are enumerated below. Scale bar in A applies to all panels. ac, anterior canal; cd, cochlear duct; eds, endolymphatic duct/sac; lc, lateral canal; pc, posterior canal; ut, utricle.