Fig. 1.

Dynamic expression of plekhg5 in early Xenopus embryos. (A-F) plekhg5 is expressed in the blastopore lip during gastrulation. Vegetal view (A,C,E) and side view of bisected embryos (B,D,F) are shown. (G-O) During neurula (G,H) and tailbud (I-O) stages, plekhg5 is expressed in the tail, hindbrain, otic and olfactory placodes, and pharyngeal pouch. Sections of the embryos reveal plekhg5 transcripts in the dorsal neural tube and the notochord. (P,Q) Expression of plekhg5 at the tadpole stages is detected in the hindbrain, otic vesicles, tail, pharyngeal pouch and the ventral-lateral mesoderm. (R-W) Sections of the tadpole embryos show expression of plekhg5 in the notochord, transiently in the trunk but persisting in the tail, the migrating neural crest cells along the ventral route and in the dorsal root ganglia, the dorsal neural tube in the tail, the tips of the outgrowing pharyngeal pouches, and the lining of the foregut. White lines in J,M,P,Q show the position of the sections in the panels indicted by the letters. The embryonic axes are labeled in each panel: D-V, dorsal-ventral; A-P, anterior-posterior; L-R, left-right.