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. 2018 Nov 19;129(1):122–136. doi: 10.1172/JCI99386

Figure 3. p110δ kinase inactivation leads to severe autoimmune phenotype in Eμ-TCL1 mice.

Figure 3

(A) Overall survival of p110δWT/WTTCL1 (n = 88) and p110δD910A/D910ATCL1 mice (n = 79). (Log-rank test P < 0.001.) (B) Histology of colon in p110δD910A/D910ATCL1 (n = 10), p110δWT/WTTCL1 (n = 10), p110δD910A/D910A (n = 10), and p110δWT/WT (n = 10) mice at 9 months of age. Both p110δD910A/D910ATCL1 and p110δD910A/D910A demonstrated severe colitis, consisting of hyperplasia of the crypt epithelium, crypt abscesses (arrows), and numerous neutrophils within the lamina propria (inset). Colitis was not observed in p110δWT/WTTCL1 and p110δWT/WT mice. Original magnification, ×20; inset, ×40.