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. 2018 Dec 10;129(1):349–363. doi: 10.1172/JCI123391

Figure 4. Anti-CTLA4 DVD reduced treatment-associated toxicity in mice.

Figure 4

Eight- to ten-week-old male Rag1–/– mice (on a C57BL/6j background) were adoptively transferred with purified CD4+CD25–CD45RBhi cells from WT mice. Recipient mice were then treated with either anti-CTLA4, anti-CTLA4 DVD, or isotype control. (A) Percentage of body weight lost among different treatment groups. (B) Mice were harvested at day 28, and multiorgan pathology was examined among different treatment groups. Arrows represent lymphocytic infiltration in the tissues. Experiments were conducted twice, and data shown are from 5 mice per group. Bars represent mean ± SEM. **P < 0.01, 2-way ANOVA with post hoc Tukey’s test.