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. 2018 Dec 10;129(1):324–335. doi: 10.1172/JCI120391

Figure 5. ABabDR4-derived TCR-3598_2 showed no alloreactivity.

Figure 5

TCR-transduced CD4+ T cells were cocultured with a panel of LCLs expressing different MHC class I and II molecules (Supplemental Table 1). As a positive control, PMA and ionomycin were added to the T cells. After overnight incubation, IL-2 was measured in the supernatant. Background, defined as the highest cytokine secretion observed for untransduced T cells, is indicated by the dotted line. Mean values of intra-assay duplicates with SD are shown. In the grid below, cross-reactions to LCLs are marked by an X. The results are representative of 3 independent experiments performed with PBLs from different donors. See also Supplemental Figure 3.