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. 2018 Dec 3;129(1):252–267. doi: 10.1172/JCI122064

Figure 8. Human macrophages from subjects carrying ALDH2 rs671 SNP have increased foam cell formation caused by the downregulation of ATP6V0E2, and autophagy due to the increased nuclear translocation of ALDH2.

Figure 8

(A) Macrophages from ALDH2*2/2*1 (n = 10) have lower ATP6V0E2 mRNA levels than those from ALDH2*1 (n = 16). (B) ALDH2 rs671 mutant increased autophagy in human macrophages treated with ox-LDL (n = 3). (C) ALDH2 rs671 mutant decreases CE hydrolysis in human macrophages (ALDH2*1, n = 16; ALDH2*2/2*1, n = 10). (D) ALDH2 rs671 SNP increases ALDH2 translocation in human macrophages treated with metformin (n = 5). Scale bars: 5 μm. Statistical comparisons were made using 2-tailed Student’s t test. All data are mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.