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Schematic diagram of the general structural model developed for the analysis. Abbreviations: BAL, bronchoalveolar lavage; CLC, central clearance; CLLP, clearance from lung to plasma; QC, intercompartmental clearance between VC and VP; QL, intercompartmental clearance between VL and VLP; VC, volume of the central plasma compartment; VL, volume of the central lung compartment; VP, volume of the peripheral tissue compartment; VLP, volume of the deep lung compartment.
