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The predicted drug concentration versus time profiles in lung showing the predicted median concentrations (line) and the corresponding 95% prediction intervals (shaded) computed from the 1000 data sets in the simulated population with variability (CV of 30%) in central clearance (CLC) following intratracheal administration of SEN001, SEN019, and SEN032 at 0.15 mg/kg every 24, 12, and 8 h (TAU).
