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. 2018 Sep 15;18:97–106. doi: 10.1016/j.molmet.2018.09.001

Figure 3.

Figure 3

Adult Nnat null mice on a 129S2/Sv background display hyperphagia and reduced energy expenditure. (A) Energy expenditure calculated by indirect calorimetry using CLAMS over a period of 96 h in young adult (P70) wild type and Nnat+/−p male mice (n = 8 mice per genotype). Black bars indicate periods of dark cycles. (B) Physical activity in the same mice as A expressed as horizontal beam breaks over time. (C) Food intake following an overnight fast in wild type and Nnat+/−p male mice (n = 10 animals per genotype). (D) Food intake alterations (percentage change) in response to exogenous leptin compared to saline crossover control in wild type and Nnat+/−p male mice (n = 12 animals per genotype). In all panels, data represented as mean ± SEM (*p < 0.05, **p < 0.01).