Table 2.

Regional distribution of¹²⁵I-ghrelins in WT and Ghsr null mice.

		mAG				hAG				mDAG				hDAG
		WT		Ghsr Null		WT		Ghsr Null		WT		Ghsr Null		WT		Ghsr Null
Brain Region	Abbreviation	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM
Whole Brain	WB	6.01	0.414	6.77	0.766	6.45	1.02	5.48	0.458	5.86	0.646	5.79	0.324	8.67	0.674	7.98	0.289
Olfactory Bulb	OB	9.31	1.044	11.43	0.399	10.2	1.49	7.79	1.07	9.46	1.01	8.57	1.19	16.1	1.74	15.9	2.22
Cortex	Ctx	5.06	0.409	5.89	0.642	5.84	0.904	5.11	0.464	5.55	0.619	5.15	0.476	7.56	0.662	6.75	0.246
Striatum	Str	8.05	0.678	8.16	1.37	6.52	1.22	4.3	0.628	3.14	0.802	5.07	0.841	5.67	0.725	6.67	0.264
Hypothalamus	Hypo	9.00	0.995	7.74	0.854	6.83	1.41	5.39	0.458	5.02	0.79	5.27	1.29	9.62	0.948	9.16	0.806
Hippocampus	Hippo	6.69	1.422	5.85	1.083	4.19	0.906	4.17	0.702	6.08	1.26	6.64	0.998	6.92	1.03	8.25	1.55
Thalamus	Thal	5.67	0.797	5.29	0.902	6.17	1.04	4.27	0.644	4.53	0.811	4.85	0.257	8.53	1.11	6.89	0.686
Cerebellum	CB	6.93	1.008	8.81	1.511	8.09	1.56	7.03	0.818	6.77	0.66	8.62	0.477	10	1.01	9.51	0.73
Midbrain	Mid	5.49	1.045	6.71	0.840	6.16	0.834	5.46	0.294	6.37	0.687	4.91	0.53	7.02	1.22	5.82	0.792
Pons-Medulla	Pons	8.33	0.939	8.50	0.661	8.09	1.37	6.8	0.465	9.04	1.44	7.54	1.05	14.8	0.965	14.1	0.791

Data are represented in Figure 3 but reported here as mean with SEM (n = 5–7/brain region). Two-Way ANOVA shows a significant effect of regional distribution for each peptide: hDAG p < 0.0001 WT (WB different from OB, Pons; OB different from all regions; Pons different from all regions) and Ghsr Null (WB different from OB, Pons; OB different from all regions; Pons different from all regions except Mid); mDAG p < 0.0001 WT (OB different from Str, Hypo, Thal; Pons different from Str, Thal); hAG p = 0.0011 WT (no post-hoc differences); mAG p < 0.0001 Ghsr Null (OB different from Ctx, Hippo, Thal, Mid).