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. 2018 Oct 4;18:79–87. doi: 10.1016/j.molmet.2018.09.010

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure S4 — MRAP2 overexpression in the PVN does not affect metabolism of male mice exposed to a standard chow diet. (A–C) Graphs showing body weight (A), fat mass (B), and lean mass (C) of male Mc4r-cre^PVN-GFPcontrol (n = 6) and Mc4r-cre^PVN-MRAP2 (n = 6) mice at 4, 8 and 12 weeks after PVN viral injections. (D and E) Graphs showing glucose tolerance (D) and insulin tolerance tests in male Mc4r-cre^PVN-GFP and Mc4r-cre^PVN-MRAP2 mice (n = 6 per group) after 3 months from the PVN viral injections. (F) and rectal body temperature in male Mc4r-cre^PVN-GFP (n = 7) and Mc4r-cre^PVN-MRAP2 mice (n = 6) after 3 months from the PVN viral injections. All data are presented as mean ± SEM.