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. 2018 Oct 4;18:79–87. doi: 10.1016/j.molmet.2018.09.010

Figure 4.

Figure 4

Selective overexpression of MRAP2 in PVN MC4R expressing neurons affects metabolism in male mice on HFD. (A–C) Graphs showing body weight (A), fat mass (B) and lean mass (C) of male Mc4r-crePVN-GFP (n = 6) and Mc4r-crePVN-MRAP2 mice (n = 6) exposed to HFD at 2 weeks after PVN viral injections. (D and E) Graphs showing food intake in male Mc4r-crePVN-GFP (n = 7), and Mc4r-crePVN-MRAP2 mice (n = 7) at 8 weeks of HFD. Cumulative food intake over a 24 h period, feeding during light and dark phases are shown. Gray area represents the dark phase. (F–I) Graphs showing locomotor activity (F), energy expenditure as a total in the 24-h cycle (G) and in the dark (H) and light (I) phases of the cycle of Mc4r-crePVN-GFP (n = 7) and Mc4r-crePVN-MRAP2 mice (n = 7) at 8 weeks of HFD. All data are presented as mean ± SEM. *P < 0.05; **P < 0.01 compared to Mc4r-crePVN-GFP mice.