Table 2.
Pathway enrichment analysis in liver and serum between fetuses from CON and OB-WSD mothers.
| Metabolite Set | Hits | FDR | Up in OB-WSD | Down in OB-WSD |
|---|---|---|---|---|
| Liver | ||||
| Arginine and proline metabolism | 7 | 0.0029 | Ornithine; l-Proline; Guanidoacetic acid; 4-Hydroxyproline; Creatinine | N-Acetylornithine; 4-(Glutamylamino) butanoate |
| Taurine and hypotaurine metabolism | 3 | 0.0507 | Acetylphosphate | Hypotaurine; 5-L-Glutamyl-taurine |
| Citrate cycle (TCA cycle) | 3 | 0.0507 | Phosphoenolpyruvate | alpha-Ketoglutarate; Oxaloacetate |
| Alanine, aspartate and glutamate metabolism | 3 | 0.0652 | Adenylosuccinate; alpha-Ketoglutarate; Oxaloacetate | |
| Glycolysis or Gluconeogenesis | 4 | 0.0993 | Phosphoenolpyruvate; 2-Phospho-d-glyceric acid; Fructose 1,6-bisphosphate | Oxaloacetate |
| Pyruvate metabolism | 3 | 0.0993 | Phosphoenolpyruvate; Acetylphosphate | Oxaloacetate |
| Serum | ||||
| beta-Alanine metabolism | 5 | 0.0007 | Aspartate; Spermidine; Dihydrouracil; Uracil; Carnosine | |
| Arginine and proline metabolism | 7 | 0.0007 | Aspartate; Glutamate; Spermidine; Pyruvate; Creatinine; Putrescine | N-Acetylornithine |
| Glutathione metabolism | 5 | 0.0015 | Glutamate; Spermidine; Putrescine | Cysteinylglycine; Ascorbate |
| Pantothenate and CoA biosynthesis | 4 | 0.0042 | Dihydrouracil; Pyruvate; Aspartate; Uracil | |
| Purine metabolism | 6 | 0.0080 | Guanine, Urate | Guanosine; Glycine; Inosine; Guanosine monophosphate |
| Alanine, aspartate and glutamate metabolism | 3 | 0.0323 | Aspartate; Pyruvate; Glutamate | |
| Pyrimidine metabolism | 4 | 0.0521 | Dihydrouracil; Uracil | Cytidine; Thymidine |
Pathways and inclusive metabolite sets with FDR < 0.10 are listed.
FDR, false discovery rate; TCA, tricarboxylic acid.