Table 1.
Study population characteristics of incident lung cancer cases and nodule‐positive controls by three nodule size classes
| Training set (C1) | Lung cancer cases | Nodule‐positive controls | ||||
|---|---|---|---|---|---|---|
|
Small (<6 mm) N = 14 |
Intermediate (6‐16 mm) N = 53 |
Large (≥16 mm) N = 16 |
Small (<6 mm) N = 40 |
Intermediate (6‐16 mm) N = 125 |
Large (≥16 mm) N = 7 |
|
| Age, mean (SD) | 66.4 (4.8) | 63.4 (5.1) | 66.3 (5.6) | 64.1 (5.2) | 64.0 (5.3) | 62.4 (5.1) |
| Sex, N (%) | ||||||
| Male | 9 (64.3) | 27 (50.9) | 8 (50.0) | 23 (57.5) | 76 (60.8) | 4 (57.1) |
| Female | 5 (35.7) | 26 (49.1) | 8 (50.0) | 17 (42.5) | 49 (39.2) | 3 (42.9) |
| Race, N (%) | ||||||
| White | 14 (100.0) | 49 (92.5) | 16 (100.0) | 39 (97.5) | 120 (96.0) | 6 (85.7) |
| Non‐White | 0 (0.00) | 4 (7.6) | 0 (0.00) | 1 (2.5) | 5 (4.0) | 1 (14.3) |
| Smoking status, N (%) | ||||||
| Former | 8 (57.1) | 24 (45.3) | 10 (62.5) | 16 (40.0) | 63 (50.4) | 5 (71.4) |
| Current | 6 (42.9) | 29 (54.7) | 6 (37.5) | 24 (60.0) | 62 (49.6) | 2 (28.6) |
| Pack‐years, mean (SD) | 70.39 (27.8) | 63.5 (23.7) | 54.8 (13.1) | 64.8 (28.3) | 65.1 (25.1) | 60.5 (19.2) |
| Family history of lung cancer | ||||||
| No | 8 (57.1) | 4 (79.3) | 11 (68.8) | 33 (82.5) | 104 (83.2) | 5 (71.4) |
| Yes | 6 (42.9) | 11 (20.8) | 5 (31.3) | 7 (17.5) | 21 (16.8) | 2 (28.6) |
| Stage | ||||||
| I | 6 (42.9) | 42 (79.3) | 12 (75.0) | — | — | — |
| II | 3 (21.4) | 5 (9.4) | 0 (0.0) | — | — | — |
| III | 1 (7.1) | 2 (3.8) | 4 (25.0) | — | — | — |
| IV | 4 (28.6) | 3 (5.7) | 0 (0.0) | — | — | — |
| NOS | 0 (0.00) | 1 (1.9) | 0 (0.00) | — | — | — |
| Histology | ||||||
| Small cell | 2 (14.3) | 0 (0.0) | 0 (0.0) | — | — | — |
| Adeno/BAC | 8 (57.1) | 35 (66.0) | 14 (87.5) | — | — | — |
| Squamous cell | 1 (7.1) | 9 (17.0) | 1 (6.3) | — | — | — |
| Other and NOS | 3 (21.4) | 9 (17.0) | 1 (6.3) | — | — | — |
| Test set (C2) |
Small (<6 mm) N = 19 |
Intermediate (6‐16 mm) N = 40 |
Large (≥16 mm) N = 18 |
Small (<6 mm) N = 20 |
Intermediate (6‐16 mm) N = 108 |
Large (≥16 mm) N = 7 |
|---|---|---|---|---|---|---|
| Age, mean (SD) | 63.4 (5.2) | 62.6 (4.4) | 63.3 (5.4) | 61.2 (4.6) | 63.1 (4.8) | 63.9 (3.5) |
| Sex, N (%) | ||||||
| Male | 12 (63.2) | 21 (52.5) | 10 (55.6) | 5 (25.0) | 67 (62.0) | 5 (71.4) |
| Female | 7 (36.8) | 19 (47.5) | 8 (44.4) | 15 (75.0) | 41 (38.0) | 2 (28.6) |
| Race, N (%) | ||||||
| White | 19 (100.0) | 38 (95.0) | 17 (94.4) | 20 (100.0) | 103 (95.4) | 7 (100.0) |
| Non‐White | 0 (0.0) | 2 (5.0) | 1 (5.6) | 0 (0.0) | 5 (4.6) | 0 (0.0) |
| Smoking status, N (%) | ||||||
| Former | 9 (47.4) | 19 (47.5) | 9 (50.0) | 9 (45.0) | 47 (43.5) | 4 (57.1) |
| Current | 10 (52.6) | 21 (52.5) | 9 (50.0) | 11 (55.0) | 61 (56.5) | 3 (42.9) |
| Pack‐years, mean (SD) | 61.3 (32.4) | 62.2 (21.5) | 66.9 (24.2) | 62.8 (21.9) | 60.2 (20.9) | 59.4 (21.4) |
| Family history of lung cancer | ||||||
| No | 13 (68.4) | 34 (85.0) | 12 (66.7) | 18 (90.0) | 91 (84.3) | 5 (71.4) |
| Yes | 6 (31.6) | 6 (15.0) | 6 (33.3) | 2 (10.0) | 17 (15.7) | 2 (28.6) |
| Stage | ||||||
| I | 10 (52.6) | 28 (70.0) | 16 (88.9) | — | — | — |
| II | 3 (15.8) | 1 (2.5) | 0 (0.0) | — | — | — |
| III | 3 (15.8) | 7 (17.5) | 0 (0.0) | — | — | — |
| IV | 3 (15.8) | 3 (7.5) | 2 (11.1) | — | — | — |
| NOS | 0 (0.0) | 1 (2.5) | 0 (0.0) | — | — | — |
| Histology | ||||||
| Small cell carcinoma | 3 (15.8) | 1 (2.5) | 0 (0.0) | — | — | — |
| Adenocarcinoma/BAC | 10 (52.6) | 23 (57.5) | 13 (72.2) | — | — | — |
| Squamous cell carcinoma | 4 (21.1) | 6 (15.0) | 1 (5.6) | — | — | — |
| Other and NOS | 2 (10.5) | 10 (25.0) | 4 (22.2) | — | — | — |