Table 3.
Incident lung cancer cases and nodule‐positive controls by nodule size with by two nodule size classes
| Training set (C1) | Lung cancer cases | Nodule‐positive controls | ||
|---|---|---|---|---|
|
Small (<6 mm) N = 14 |
Large (≥6 mm) N = 69 |
Small (<6 mm) N = 40 |
Large (≥6 mm) N = 132 |
|
| Age, mean (SD) | 66.4 (4.8) | 64.1 (5.3) | 64.1 (5.2) | 63.9 (5.3) |
| Sex, N (%) | ||||
| Male | 9 (64.3) | 35 (50.7) | 23 (57.5) | 80 (60.6) |
| Female | 5 (35.7) | 34 (49.3) | 17 (42.5) | 52 (39.4) |
| Race, N (%) | ||||
| White | 14 (100.0) | 65 (94.2) | 39 (97.5) | 126 (95.5) |
| Non‐White | 0 (0.0) | 4 (5.8) | 1 (2.5) | 6 (4.6) |
| Smoking status, N (%) | ||||
| Former | 8 (57.1) | 34 (49.3) | 16 (40.0) | 68 (51.5) |
| Current | 6 (42.9) | 35 (50.7) | 24 (60.0) | 64 (48.5) |
| Pack‐years, mean (SD) | 70.3 (27.8) | 61.5 (22.0) | 64.8 (28.3) | 64.8 (24.8) |
| Family history of lung cancer | ||||
| No | 8 (57.1) | 53 (76.8) | 33 (82.5) | 109 (82.6) |
| Yes | 6 (42.9) | 16 (23.2) | 7 (17.5) | 23 (17.4) |
| Stage | ||||
| I | 6 (42.9) | 54 (78.3) | — | — |
| II | 3 (21.4) | 5 (7.3) | — | — |
| III | 1 (7.1) | 6 (8.7) | — | — |
| IV | 4 (28.6) | 3 (4.4) | — | — |
| NOS | 0 (0.00) | 1 (1.5) | — | — |
| Histology | ||||
| Small cell | 2 (14.3) | 0 (0.0) | — | — |
| Adeno/BAC | 8 (57.1) | 49 (71.0) | — | — |
| Squamous cell | 1 (7.1) | 10 (14.5) | — | — |
| Other and NOS | 3 (21.4) | 10 (14.5) | — | — |
| Test Set (C2) |
Small (<6 mm) N = 19 |
Large (≥6 mm) N = 58 |
Small (<6 mm) N = 20 |
Large (≥6 mm) N = 115 |
|---|---|---|---|---|
| Age, mean (SD) | 63.4 (5.2) | 62.8 (4.7) | 61.2 (4.6) | 63.2 (4.7) |
| Sex, N (%) | ||||
| Male | 12 (63.2) | 31 (53.5) | 5 (25.0) | 72 (62.6) |
| Female | 7 (36.8) | 27 (46.5) | 15 (75.0) | 43 (37.4) |
| Race, N (%) | ||||
| White | 19 (100.0) | 55 (94.8) | 20 (100.0) | 110 (95.7) |
| Non‐White | 0 (0.0) | 3 (5.2) | 0 (0.0) | 5 (4.4) |
| Smoking status, N (%) | ||||
| Former | 9 (47.4) | 28 (48.3) | 9 (45.0) | 51 (44.4) |
| Current | 10 (52.6) | 30 (51.7) | 11 (55.0) | 64 (55.7) |
| Pack‐years, mean (SD) | 61.3 (32.4) | 63.6 (22.3) | 62.8 (21.9) | 60.1 (20.9) |
| Family history of lung cancer | ||||
| No | 13 (68.4) | 46 (79.3) | 18 (90.0) | 96 (83.5) |
| Yes | 6 (31.6) | 12 (20.7) | 2 (10.0) | 19 (16.5) |
| Stage | ||||
| I | 10 (52.6) | 44 (75.9) | — | — |
| II | 3 (15.8) | 1 (1.7) | — | — |
| III | 3 (15.8) | 7 (12.1) | — | — |
| IV | 3 (15.8) | 5 (8.6) | — | — |
| NOS | 0 (0.0) | 1 (1.7) | — | — |
| Histology | ||||
| Small cell carcinoma | 3 (15.8) | 1 (1.7) | — | — |
| Adenocarcinoma/BAC | 10 (52.6) | 36 (62.1) | — | — |
| Squamous cell carcinoma | 4 (21.1) | 7 (12.1) | — | — |
| Other and NOS | 2 (10.5) | 14 (24.1) | — | — |