Pyruvate‐competitive |
Oxamate |
Gastric cancer; cervical cancer |
No |
Limited membrane permeability |
110, 111
|
NADH‐competitive |
Gossypol |
Melanoma; lung cancer; breast cancer; cervical cancer; leukemia; glioma; adrenal cancer |
Yes |
Non‐specific toxicity |
112, 113, 114, 115, 116, 117, 118
|
FX11 |
B‐lymphoma; pancreatic cancer |
No |
Highly reactive catechol portion of this molecule |
3, 5, 120
|
Quinoline 3‐sulfonamides |
Hepatocellular carcinoma |
No |
Low clearance in the body and incompatible with oral bioavailability |
55
|
Pyruvate and NADH competitive |
NHI |
Pancreatic ductal adenocarcinoma; cervical cancer |
Unknown |
Unknown |
9, 120, 121
|
Binding the free enzyme |
Galloflavin |
Breast cancer; hepatocellular carcinoma |
Unknown |
Unknown |
122, 123, 124
|