Table 2.
The relationship between gender status and genetic polymorphisms in five selected genes
| Groups | Male | OR (95% CI) | Female | OR (95% CI) | ||
|---|---|---|---|---|---|---|
| Cases (%) | Controls (%) | Cases (%) | Cases (%) | |||
| ERCC1 rs3212986 | ||||||
| CC | 93 (49.5) | 115 (61.2) | 1.000 | 59 (52.7) | 59 (52.7) | 1.000 |
| CA | 74 (39.4) | 65 (34.6) | 1.408 (0.915‐2.166) | 47 (42.0) | 46 (41.1) | 1.022 (0.593‐1.760) |
| AA | 21 (11.1) | 8 (4.2) | 3.246 (1.375‐7.663)[Link] | 6 (5.3) | 7 (6.2) | 0.857 (0.272‐2.703) |
| ERCC1 rs735482 | ||||||
| AA | 64 (34.0) | 45 (23.9) | 1.000 | 28 (25.0) | 34 (30.4) | 1.000 |
| AC | 89 (47.3) | 100 (53.2) | 0.626 (0.389‐1.008) | 61 (54.5) | 60 (53.6) | 1.235 (0.668‐2.282) |
| CC | 35 (18.6) | 43 (22.9) | 0.572 (0.318‐1.029) | 23 (20.5) | 18 (16.0) | 1.522 (0.701‐3.433) |
| ERCC1 rs2336219 | ||||||
| GG | 64 (34.0) | 47 (25.0) | 1.000 | 28 (25.0) | 36 (32.1) | 1.000 |
| GA | 90 (47.9) | 103 (54.8) | 0.642 (0.401‐1.208) | 61 (54.5) | 59 (52.7) | 1.329 (0.722‐2.446) |
| AA | 34 (18.1) | 38 (20.2) | 0.657 (0362‐1.193) | 23 (20.5) | 17 (15.2) | 1.739 (0.783‐3.864) |
| MLH3 rs108621 | ||||||
| TT | 123 (65.4) | 125 (66.5) | 1.000 | 67 (59.8) | 76 (67.9) | 1.000 |
| TC | 55 (29.3) | 58 (30.9) | 0.964 (0.618‐1.504) | 41 (36.6) | 32 (28.6) | 1.453 (0.824‐2.563) |
| CC | 10 (5.3) | 5 (2.7) | 2.033 (0.675‐6.118) | 4 (6.6) | 4 (3.5) | 1.134 (0.273‐4.713) |
| OGG1 rs1052133 | ||||||
| GG | 62 (33.0) | 62 (33.0) | 1.000 | 34 (30.4) | 34 (39.3) | 1.000 |
| GC | 94 (50.0) | 94 (50.0) | 1.000 (0.635‐1.574) | 60 (53.6) | 59 (52.7) | 1.316 (0.741‐2.336) |
| CC | 32 (17.0) | 32 (17.0) | 1.000 (0.547‐1.828) | 18 (16.1) | 9 (8.0) | 2.588 (1.035‐6.474)[Link] |
| PPP1R13L rs6966 | ||||||
| TT | 51 (27.1) | 54 (28.7) | 1.000 | 29 (25.9) | 31 (27.7) | 1.000 |
| TA | 89 (47.3) | 80 (42.6) | 1.178 (0.723‐1.918) | 56 (50.0) | 50 (44.6) | 1.197 (0.635‐2.257) |
| AA | 48 (25.6) | 54 (28.7) | 0.941 (0.545‐1.624) | 27 (24.1) | 31 (27.7) | 0.931 (0.452‐1.918) |
| CD3EAP rs1007616 | ||||||
| CC | 102 (54.3) | 116 (61.7) | 1.000 | 57 (50.9) | 62 (55.3) | 1.000 |
| CT | 66 (35.1) | 61 (32.4) | 1.230 (0.794‐1.907) | 49 (43.8) | 39 (34.8) | 1.367 (0.786‐2.377) |
| TT | 20 (10.6) | 11 (5.9) | 2.068 (0.946‐4.521) | 6 (5.3) | 11 (9.9) | 0.593 (0.206‐1.709) |
χ2 = 7.824 P = 0.005.
χ2 = 4.273 P = 0.039.