Table 3.
The relationship between age status and genetic polymorphisms in five selected genes
| Groups | Age < 60 (y) | OR (95% CI) | Age ≥ 60 (y) | OR (95% CI) | ||
|---|---|---|---|---|---|---|
| Cases (%) | Controls (%) | Cases (%) | Controls (%) | |||
| ERCC1 rs3212986 | ||||||
| CC | 67 (45.0) | 85 (53.8) | 1.000 | 85 (56.3) | 89 (62.7) | 1.000 |
| CA | 68 (45.6) | 63 (39.9) | 1.369 (0.857‐2.189) | 53 (35.1) | 48 (33.8) | 1.248 (0.891‐1.748) |
| AA | 14 (9.4) | 10 (6.3) | 1.776 (0.742‐4.250) | 13 (8.6) | 5 (3.5) | 2.722 (0.931‐7.964) |
| ERCC1 rs735482 | ||||||
| AA | 53 (35.6) | 40 (25.3) | 1.000 | 39 (25.8) | 39 (27.5) | 1.000 |
| AC | 72 (48.3) | 97 (61.4) | 0.560 (0.336‐0.934)[Link] | 78 (51.7) | 63 (44.4) | 1.238 (0.711‐2.155) |
| CC | 24 (16.1) | 21 (13.3) | 0.863 (0.422‐1.764) | 34 (22.5) | 40 (28.1) | 0.850 (0.449‐1.607) |
| ERCC1 rs2336219 | ||||||
| GG | 53 (35.6) | 42 (26.6) | 1.000 | 39 (25.8) | 41 (28.9) | 1.000 |
| GA | 74 (49.7) | 95 (60.1) | 0.617 (0.372‐1.024) | 77 (51.0) | 67 (47.2) | 1.208 (0.699‐2.088) |
| AA | 22 (14.8) | 21 (13.3) | 0.830 (0.403‐1.709) | 35 (23.2) | 34 (23.9) | 1.082 (0.568‐2.061) |
| MLH3 rs108621 | ||||||
| TT | 96 (64.4) | 100 (63.3) | 1.000 | 94 (62.3) | 101 (71.1) | 1.000 |
| TC | 46 (30.9) | 55 (34.8) | 0.871 (0.538‐1.410) | 50 (33.1) | 35 (24.6) | 1.535 (0.917‐2.570) |
| CC | 7 (4.7) | 3 (1.9) | 2.431 (0.611‐9.673) | 7 (4.6) | 6 (4.3) | 1.254 (0.407‐3.865) |
| OGG1 rs1052133 | ||||||
| GG | 41 (27.5) | 61 (38.6) | 1.000 | 55 (36.4) | 45 (31.7) | 1.000 |
| GC | 85 (57.0) | 78 (49.4) | 1.621 (0.982‐2.676) | 69 (45.7) | 75 (52.8) | 0.753 (0.451‐1.256) |
| CC | 23 (15.4) | 19 (12.0) | 1.801 (0.872‐3.719) | 27 (17.9) | 22 (15.5) | 1.004 (0.505‐1.996) |
| PPP1R13L rs6966 | ||||||
| TT | 37 (24.8) | 43 (27.2) | 1.000 | 43 (28.5) | 42 (29.6) | 1.000 |
| TA | 70 (47.0) | 68 (43.1) | 1.196 (0.689‐2.077) | 75 (49.6) | 62 (43.7) | 1.182 (0.687‐2.032) |
| AA | 42 (28.2) | 47 (29.7) | 1.039 (0.567‐1.902) | 33 (21.9) | 38 (26.7) | 0.848 (0.451‐1.594) |
| CD3EAP rs1007616 | ||||||
| CC | 83 (55.7) | 96 (60.8) | 1.000 | 76 (50.3) | 82 (57.7) | 1.000 |
| CT | 53 (35.6) | 55 (34.8) | 1.115 (0.691‐1.798) | 62 (41.1) | 45 (31.7) | 1.487 (0.906‐2.438) |
| TT | 13 (8.7) | 7 (4.4) | 2.148 (0.819‐5.636) | 13 (8.6) | 15 (10.6) | 0.935 (0.418‐2.093) |
χ2 = 4.976, P = 0.026.