Table 4.

Multivariable Cox regression models predicting survival outcomes in patients with upper tract urothelial carcinoma

Variables	Cancer‐specific survival				Recurrence‐free survival				Overall survival
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Tumor grade (high vs low)	1.88 (1.15‐3.07)	0.012	1.72 (1.05‐2.83)	0.033	1.31 (0.93‐1.86)	0.123	1.25 (0.88‐1.77)	0.211	1.63 (1.09‐2.45)	0.018	1.50 (1.00‐2.26)	0.052
pT stage (≥pT3 vs ≤pT2)	2.19 (1.51‐3.17)	<0.0001	2.15 (1.48‐3.12)	<0.0001	2.00 (1.50‐2.68)	<0.0001	1.98 (1.48‐2.66)	<0.0001	2.10 (1.52‐2.89)	<0.0001	2.08 (1.50‐2.88)	<0.0001
Lymph node status (pN+ vs pN0/x)	2.22 (1.56‐3.17)	<0.0001	2.32 (1.62‐3.33)	<0.0001	2.30 (1.67‐3.16)	<0.0001	2.40 (1.74‐3.31)	<0.0001	2.08 (1.49‐2.90)	<0.0001	2.17 (1.54‐3.04)	<0.0001
Tumor size (≥3 cm vs <3 cm)	1.59 (1.13‐2.26)	0.009	1.74 (1.22‐2.47)	0.002	1.50 (1.13‐1.98)	0.005	1.58 (1.19‐2.10)	0.001	1.59 (1.17‐2.16)	0.003	1.71 (1.26‐2.33)	0.001
Architecture (Sessile vs Papillary)	1.88 (1.19‐2.96)	0.006	1.80 (1.14‐2.84)	0.012	1.50 (1.08‐2.10)	0.017	1.45 (1.04‐2.03)	0.030	1.60 (1.10‐2.32)	0.014	1.53 (1.05‐2.23)	0.001
CVH (yes vs no)	1.48 (1.08‐2.01)	0.014	1.36 (0.99‐1.87)	0.055	1.30 (1.00‐1.70)	0.054	1.24 (0.95‐1.63)	0.120	1.39 (1.05‐1.85)	0.021	1.30 (0.98‐1.73)	0.074
CONUT score				<0.0001				0.003				<0.0001
Light vs Normal			1.69 (1.21‐2.34)	0.002			1.43 (1.10‐1.86)	0.008			1.58 (1.18‐2.11)	0.002
Moderate/severe vs Normal			2.39 (1.55‐3.68)	<0.0001			1.80 (1.24‐2.60)	0.002			2.26 (1.53‐3.34)	<0.0001
Predictive accuracy	75.5%		77.2%		71.5%		72.3%		74.5%		75.6%

CONUT, controlling nutritional status; CVH, concomitant variant histology; HR, hazard ratio.