Table 2.
Association between GRM SNPs and RCC risk
| Gene | SNP | Genotype | Cases, n (%) | Controls, n (%) | OR (95% CI) | P | q | OR (95% CI)a | P a |
|---|---|---|---|---|---|---|---|---|---|
| GRM5 | rs7102764 | AA | 209 (54.3) | 249 (63.8) | |||||
| AT | 151 (39.2) | 125 (32.1) | |||||||
| TT | 25 (6.5) | 16 (4.1) | |||||||
| Trend | 1.41 (1.11‐1.79) | 0.005 | 0.140 | 1.42 (1.11‐1.83) | 0.006 | ||||
| GRM7 | rs756084 | CC | 100 (26.0) | 119 (30.5) | |||||
| CA | 191 (49.6) | 197 (50.5) | |||||||
| AA | 94 (24.4) | 74 (19.0) | |||||||
| Trend | 1.22 (1.00‐1.50) | 0.049 | 0.403 |
95% CI, 95% confidence interval; OR, odds ratio; RCC, renal cell carcinoma; SNP, single‐nucleotide polymorphism.
q < 0.20 are in boldface.
a
ORs were adjusted for age, gender, alcohol consumption, and histories of hypertension and diabetes.