Table 3.
Association between GRM SNPs and overall survival in patients with RCC
| Gene | SNP | Genotype | n of patients | n of events | 5‐y survival rate (%) | P a | q | HR (95% CI)b | P b |
|---|---|---|---|---|---|---|---|---|---|
| GRM3 | rs701332 | TT | 235 | 5 | 96.6 | ||||
| TC | 42 | 4 | 81.6 | ||||||
| Trend | 0.015 | 0.133 | 4.28 (1.15‐16.0) | 0.030 | |||||
| GRM4 | rs2499707 | CC | 192 | 3 | 96.7 | ||||
| CT | 70 | 4 | 89.9 | ||||||
| TT | 11 | 2 | 70.0 | ||||||
| Trend | 0.001 | 0.028 | 3.55 (1.46‐8.65) | 0.005 | |||||
| GRM4 | rs4713742 | CC | 117 | 2 | 96.1 | ||||
| CT | 117 | 2 | 97.6 | ||||||
| TT | 35 | 4 | 82.1 | ||||||
| Trend | 0.018 | 0.133 | 3.11 (1.17‐8.27) | 0.023 | |||||
| n of risk alleles | |||||||||
| 0 | 69 | 0 | 100.0 | ||||||
| 1‐2 | 149 | 3 | 95.8 | ||||||
| >2 | 28 | 5 | 70.6 | ||||||
| Trend | <0.001 | 10.4 (2.73‐39.8) | 0.001 | ||||||
95% CI, 95% confidence interval; HR, hazard ratio; RCC, renal cell carcinoma; SNP, single‐nucleotide polymorphism.
q < 0.20 are in boldface.
a
P values were calculated using the log‐rank test.
b
HRs were adjusted for age and gender.