FIGURE 1.

Model of Simian Varicella Virus (SVV) pathogenesis in rhesus macaques following intrabronchial inoculation. Intrabronchial inoculation of rhesus macaques with SVV results in primary infection associated with viral replication in the lung, T cell viremia and the development of varicella. SVV reaches sensory ganglia as early as 3 days post infection. Initial viral replication is followed by the establishment of latency in the sensory ganglia. SVV can reactivate upon immune suppression. Both primary infection and viral reactivation induce robust cellular and humoral immune responses.