Table 2.
Genomic risk loci from the discovery sample which are not genome-wide significant in IGAP.
| CHR | BP | SNP | A1/A2 | MAF | Gene | Discovery | Replication | Combined | Dir. | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | p-value | OR | p-value | OR | p-value | |||||||
| 4 | 11676144 | rs6448807 | T/C | 0.30 |
RP11-281P23.2 (HS3ST1) |
1.08 | 2.23E-08 | 1.03 | 1.72E-01 | 1.07 | 2.48E-08 | +++ |
| 10 | 11720308 | rs7920721 | G/A | 0.27 |
RP11-138I18.2 (USP6NL/ECHDC3) |
1.07 | 1.82E-08 | 1.06 | 7.23E-03 | 1.07 | 4.84E-10 | +++ |
| 14 | 107156009 | rs79452530 | T/C | 0.16 |
IGHV1-68
(IGHV1-68) |
0.89 | 2.36E-08 | 0.97 | 3.08E-01 | 0.91 | 1.27E-07 | — |
| 17 | 56404349 | rs2526378 | G/A | 0.47 |
BZRAP1-AS1
(BZRAP1) |
0.93 | 3.64E-09 | 0.99 | 6.69E-01 | 0.94 | 5.30E-08 | — |
CHR: chromosome; BP: base pair location; A1/A2: major/minor alleles; MAF: minor allele frequency in 1000 G. Gene: nearest gene and nearest protein-coding gene (in parentheses). OR: odds ratio; Dir.: direction of effects in the two discovery samples (Demgene, IGAP) and the replication sample (Iceland).