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. 2018 Dec 26;3(1):282–290. doi: 10.1089/can.2018.0014

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© Ruth Gallily et al. 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 4. — Anti-inflammatory (A) and antinociceptive (B) effects of intraperitoneally injected CBD or essential oils from each of the three Cannabis chemotypes Tisza (T1), Felina (T2), and Ferimon (T3). (A) Prevention of zymosan-induced swelling of hind paw; 1.5% zymosan in 40 μL was injected into the subplanter surface of the right hind paw. Immediately thereafter, CBD (5 mg/kg) or essential oils (10, 25, or 50 mg/kg) dissolved in vehicle containing ethanol:Cremophore:saline at a ratio of 1:1:18 was injected intraperitoneally. The paw thickness indicative for paw swelling was measured 2, 6, and 24 h thereafter. The paw thickness of untreated mice was 2.3 mm, which made the baseline of the graph. N=9 in each treatment group. *p<0.05, **p<0.01. (B) The hyperalgesia occurring after zymosan injection in control and treated mice as described in (A) was measured by using the von Frey nociceptive filament assay. The higher the paw withdrawal threshold, the higher is the antinociceptive effect of the drug. N=9 in each treatment group. *p<0.05, **p<0.01. CBD, cannabidiol.