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. 2018 Dec 21;9:3070. doi: 10.3389/fimmu.2018.03070

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Copyright © 2018 Fekete, Sütö, Bencze, Mázló, Szabo, Biro, Bacsi and Pazmandi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TLR9-stimulated primary human pDCs and RIG-I-activated moDCs but not RIG-I-activated pDC require glycolytic metabolism to induce allogeneic naïve T cell proliferation. (A–F) CFSE-labeled allogeneic naïve CD8⁺ T cells were co-cultured with pDCs or moDCs pre-treated with the indicated reagents. After 5 days of co-cultivation, cell division was measured by flow cytometry. (A–C) Representative histograms are shown where numbers indicate the percentage of viable dividing CD8⁺ T cells. (D–F) Bar graphs represent the mean ± SD of four independent experiments. ***p < 0.001, ****p < 0.0001 vs. control; ^###p < 0.001, ^####p < 0.0001, 2-DG: 2-deoxy-D-glucose; ND, not determined, RIGL, RIG-I ligand.