Table 4.
C4d+ WER sample details
| Patient (based on heat map cluster location, Figure 2) | Biopsy type | ABO status | DSA status (at time of biopsy) | Time from transplant to biopsy, d | Transcript geometric mean | AbMR transcripts | Heat map group | Follow-up biopsy | Follow-up biopsy type | Time to follow-up, d |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | P | i | Negative | 97 | 22.81 | Low | No Rejection | No AbMR | FC | 665 |
| 4 | FC | c | Negative | 9 | 23.19 | Low | No Rejection | None | N/A | 0 |
| 5 | FC | c | Negative | 11 | 27.16 | Low | No Rejection | No AbMR | FC | 112 |
| 9 | FC | c | Negative | 40 | 28.67 | Low | No Rejection | AbMR | FC | 1792 |
| 10 | FC | c | Negative | 115 | 21.38 | Low | No Rejection | None | N/A | 0 |
| 11 | FC | c | Positive | 12 | 22.97 | Low | No Rejection | No AbMR | FC | 44 |
| 12 | FC | c | Negative | 362 | 28.64 | Low | No Rejection | No AbMR | FC | 1386 |
| 14 | FC | i | Negative | 1169 | 34.67 | Low | No Rejection | No AbMR | FC | 755 |
| 15 | FC | c | Negative | 1530 | 27.19 | Low | No Rejection | None | N/A | 0 |
| 16 | FC | c | Negative | 59 | 31.63 | Low | No Rejection | No AbMR | P | 1075 |
| 17 | FC | c | Negative | 179 | 33.43 | Low | No Rejection | No AbMR | FC | 1687 |
| 18 | P | i | Negative | 1914 | 31.85 | Low | No Rejection | None | N/A | 0 |
| 20 | FC | c | Negative | 2853 | 32.22 | Low | No Rejection | None | N/A | 0 |
| 22 | P | i | Negative | 1827 | 28.30 | Low | No Rejection | None | N/A | 0 |
| 23 | FC | c | Positive | 62 | 31.13 | Low | No Rejection | No AbMR | P | 252 |
| 25 | P | c | Positive | 495 | 24.78 | Low | No Rejection | None | N/A | 0 |
| 29 | P | i | Negative | 1201 | 25.13 | Low | No Rejection | None | N/A | 0 |
| 31 | P | i | Negative | 260 | 23.82 | Low | No Rejection | None | N/A | 0 |
| 33 | FC | c | Negative | 132 | 44.26 | Low | No Rejection | AbMR | FC | 2164 |
| 35 | FC | c | Negative | 1282 | 32.55 | Low | No Rejection | No AbMR | FC | 1083 |
| 36 | P | i | Negative | 1886 | 31.87 | Low | No Rejection | None | N/A | 0 |
| 38 | FC | c | Positive | 41 | 37.88 | Low | No Rejection | AbMR | FC | 170 |
| 40 | FC | c | Negative | 44 | 44.52 | Low | No Rejection | No AbMR | FC | 1133 |
| 41 | FC | c | Negative | 48 | 33.80 | Low | No Rejection | None | N/A | 0 |
| 43 | FC | c | Positive | 23 | 33.62 | Low | No Rejection | No AbMR | FC | 2483 |
| 45 | FC | c | Positive | 17 | 29.25 | Low | No Rejection | AbMR | FC | 2370 |
| 47 | FC | c | Positive | 123 | 31.98 | Low | No Rejection | AbMR | FC | 1262 |
| 51 | FC | c | Positive | 1822 | 44.81 | Low | No Rejection | None | N/A | 0 |
| 52 | FC | c | Positive | 16 | 42.89 | Low | No Rejection | AbMR | FC | 28 |
| 53 | FC | c | Positive | 17 | 26.55 | Low | No Rejection | None | N/A | 0 |
| 55 | P | i | Negative | 1897 | 19.84 | Low | No Rejection | None | N/A | 0 |
| 57 | FC | c | Positive | 13 | 22.75 | Low | No Rejection | No AbMR | FC | 694 |
| 58 | P | c | Negative | 1918 | 28.40 | Low | No Rejection | None | N/A | 0 |
| 59 | FC | i | Negative | 107 | 26.78 | Low | No Rejection | None | N/A | 0 |
| 60 | FC | c | Positive | 18 | 22.42 | Low | No Rejection | No AbMR | FC | 1250 |
| 62 | FC | c | Negative | 7 | 20.09 | Low | No Rejection | AbMR | FC | 1984 |
| 65 | P | i | Negative | 238 | 13.59 | Low | No Rejection | AbMR | P | 2932 |
| 66 | FC | c | Positive | 2422 | 13.09 | Low | No Rejection | None | N/A | 0 |
| 67 | FC | c | Positive | 14 | 21.01 | Low | No Rejection | None | P | 0 |
| 68 | FC | c | Negative | 565 | 24.38 | Low | No Rejection | No AbMR | FC | 1183 |
| 69 | FC | c | Negative | 660 | 34.42 | Low | No Rejection | No AbMR | FC | 1289 |
| 70 | P | i | Negative | 92 | 36.03 | Low | No Rejection | No AbMR | P | 301 |
| 71 | P | i | Negative | 262 | 47.18 | Low | No Rejection | None | N/A | 0 |
| 92 | FC | c | Positive | 37 | 84.80 | High | Rejection | AbMR | FC | 120 |
| 95 | FC | c | Positive | 348 | 148.11 | High | Rejection | AbMR | FC | 198 |
| 106 | P | c | Negative | 1111 | 66.44 | High | Rejection | AbMR | FC | 2234 |
| 116 | FC | c | Negative | 23 | 61.94 | High | Rejection | No AbMR | C | 16 |
| 117 | FC | c | Negative | 40 | 72.78 | High | Rejection | AbMR | P | 160 |
| 119 | FC | c | Negative | 37 | 58.63 | Low | Rejection | AbMR | P | 319 |
| 120 | FC | c | Positive | 20 | 59.51 | High | Rejection | AbMR | FC | 9 |
| 121 | FC | c | Negative | 434 | 56.26 | Low | Rejection | No AbMR | FC | 3108 |
| 122 | FC | c | Negative | 16 | 74.30 | High | Rejection | AbMR | P | 340 |
| 125 | FC | c | Positive | 0 | 25.20 | Low | Rejection | AbMR | P | 206 |
AbMR, antibody-mediated rejection; c, compatible; C4d+ WER, C4d-positive without evidence of rejection; DSA, donor-specific antibody; FC, for cause biopsy; I, incompatible; N/A, not applicable; P, protocol biopsy.