Table 3.
Sources of cortical responses evoked by STN DBS in patients with Parkinson's disease.
| Subject PD | Peak type | Peak time (ms) | Fit time (ms) | x (mm) | y (mm) | z (mm) | Q (nAm) | g (%) | Location | P (%) | Orientation | SSS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PD 1 | Pos1 | 4 | 6 | −13 | −22 | 18 | 50 | 88 | Thalamus | 67 | Ventral/lateral | y |
| PD 1 | Pos2 | 13 | 10 | −7 | −25 | 47 | 13 | 93 | PreCG | 40 | Lateral | y |
| PD 1 | Neg1 | 33 | 18 | −24 | −25 | 56 | 7 | 93 | PreCG | 36 | Anterior | y |
| PD 2 | Pos1 | 4 | 6 | −31 | −15 | 42 | 13 | 93 | PreCG | 13 | Anterior/ventral | y |
| PD 2 | Pos2 | 11 | 14 | −35 | −12 | 46 | 10 | 97 | PreCG | 26 | Anterior | y |
| PD 2 | Neg1 | 36 | 43 | −37 | −14 | 48 | 10 | 97 | PreCG | 45 | Posterior | y |
| PD 3 | Pos1 | 4 | 7 | −18 | −19 | 37 | 10 | 95 | PreCG | 1 | Lateral | y |
| PD 3 | Pos2 | 11 | 14 | 1 | 45 | 24 | 10 | 86 | PCG | 70 | Ventral/medial | y |
| PD 3 | Neg1 | 21 | 22 | −8 | −21 | 54 | 12 | 98 | PreCG | 24 | Medial/posterior | y |
| PD 4 | Pos1 | 4 | 3 | 2 | −51 | 20 | 59 | 80 | Cin PD | 43 | Dorsal/lateral | y |
| PD 4 | Pos2 | 12 | 12,5 | 43 | −61 | 54 | 13 | 97 | LOC | 51 | Anterior | y |
| PD 4 | Neg1 | 26 | 24 | 28 | −40 | 34 | 34 | 96 | SPL | 2 | Posterior/medial | y |
| PD 5 | Pos1 | 4 | 3,5 | −13 | −33 | 28 | 22 | 93 | CWM | 100 | Anterior/lateral | y |
| PD 5 | Pos2 | 11 | 9 | −32 | −30 | 50 | 9 | 97 | PostGC | 34 | Anterior | y |
| PD 5 | Neg1 | 21 | 24 | −25 | −27 | 48 | 14 | 99 | PreCG | 7 | Posterior | y |
| PD 6 | Pos1 | 4 | 4 | 7 | −38 | 3 | 120 | 89 | Cin PD | 7 | Dorsal | y |
| PD 6 | Pos2 | 11 | 11 | −51 | −25 | 34 | 5 | 93 | SMG AD | 22 | Anterior | y |
| PD 6 | Neg1 | 27 | 26 | −36 | −18 | 20 | 19 | 98 | COC | 23 | Posterior | y |
| PD 7 | Pos1 | 4 | 6 | −7 | −11 | 25 | 18 | 88 | CWM | 54 | Anterior | y |
| PD 7 | Pos2 | 11 | 11 | −55 | 9 | 39 | 1 | 74 | PreCG | 52 | Ventral/anterior | y |
| PD 7 | Neg1 | 26 | 29 | −30 | 13 | 16 | 7 | 92 | COC | 2 | Medial/anterior | y |
| Mean ± SD | Pos1 | 4 ± 0 | 5 ± 2 | 11 ± 12 | −27 ± 14 | 25 ± 13 | 42 ± 40 | 90 ± 5 | ||||
| Pos2 | 11 ± 1 | 12 ± 2 | 32 ± 21 | −14 ± 33 | 42 ± 11 | 9 ± 4 | 91 ± 8 | |||||
| Neg1 | 27 ± 6 | 27 ± 8 | 27 ± 10 | −19 ± 16 | 40 ± 16 | 15 ± 9 | 96 ± 3 |
Peak type indicates the direction of the sensor level peak. Peak time is the time of the peak in the filtered responses and Fit time is the time with the best goodness-of-fit ±1 ms from the peak (±5 ms for Neg1). The values in the subsequent columns refer to the latter point in time. Dipole coordinates (x, y, z) are provided in Montreal Neurological Institute Space. The sign of the x-coordinates was flipped in patients who underwent left sided DBS before calculating the mean and standard deviation (SD). Q indicates the dipole moment and g indicates the goodness of fit. P is the probability that the dipole is truly located in the brain area given in the column Location. Only the label with maximum probability is listed. SSS indicates whether Signal Space Separation was applied. Cin PD = cingulate, posterior division, COC = central opercular cortex, CWM = cerebral white matter, LOC = lateral occipital cortex, PCG = paracingulate gyrus, PostCG = postcentral gyrus, PreCG = precentral gyrus, SMG AD = supramarginal gyrus, anterior division, SPL = superior parietal lobule.