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View full-text article in PMC

. 2018 Sep 19;18:143–152. doi: 10.1016/j.molmet.2018.09.005

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

AKR-dependent MG detoxification in human erythrocytes. Concentration of Hydroxyacetone (A) and d-lactate (B) in the RBCs from healthy controls and type 2 diabetic patients (T2D) with or without late diabetic complications. Data represent mean ± SEM (N = 15 per group); ***p < 0.001. Correlation of hydroxyacetone and AKR activity (C) or d-lactate and GLO1 activity (D) in the RBCs from healthy controls and type 2 diabetic patients (T2D) with or without late diabetic complications. Data represents mean ± SEM (N = 15 per group). E: Proposed detoxification mechanisms taking place in liver and kidney of Glo-deficient mice and men.