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. 2018 Dec 21;9:1874. doi: 10.3389/fpls.2018.01874

FIGURE 4.

FIGURE 4

Schematic representation of the different approaches to test for unintended changes in the genome of a gene-editing organism. In the center is the proposed ‘in vivo testing approach’ by both whole genome sequencing (WGS) and ‘omics’ techniques for the assessment of off-target effects in the recipient’s genome.