Figure 1.

Glucose tolerance affects adipocyte transcriptional programs in human obesity. A-B. PCA (A) and Volcano plot (B) representation of RNA-Seq data from adipocytes of Insulin Sensitive (IS) and Resistant (IR) donors. C. PCA plot representation of RNA-Seq data from adipocytes of donors with Normal (NGT) or impaired (IGF and/or IGT) Glucose Tolerance. D-E. PCA plot (D) and Volcano Plot (E) representation of RNA-Seq data from adipocytes of donors with Normal (NGH) or Impaired (IGH) glucose homeostasis. Differentially Expressed Genes (DEGs) are represented as green (down-regulated) or red (up-regulated) dots. F-G. KEGG Pathway Analysis (F) of DEGs in IGH vs NGH samples and Heatmap representation (G) of those clustered in enriched pathways (colored dots indicate the respective KEGG terms).