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. 2018 Sep 19;18:42–50. doi: 10.1016/j.molmet.2018.09.004

Figure 2.

Figure 2

Insulin sensitivity is a modifier of adipocyte transcriptional programs imposed by glucose tolerance. A. ISI Matsuda Index in NGH or IGH donors. Horizontal bars indicate the median. Significance explained in Table 1. B-C. Volcano plot representation of RNA-Seq data from adipocytes of NGH vs IGH donors featuring insulin sensitivity (B), or resistance (C). D-E. KEGG pathway analysis of DEGs in IS_IGH_NGH (D) and IR_IGH_NGH (E). F. Enrichr-based grid representation of transcriptional regulatory clusters. Left part: ChEA-based enriched transcription factors in DEGs from IS_IGH_NGH (top) or IR_IGH_NGH (bottom). p-value < 0.05 is considered statistically significant. Cluster 1 – RNF2, JARID2, PAX3; Cluster 2 – EZH2, p53, GATA2; Cluster 3 – SUZ12, SMAD, ZNF217, ESR1, CEBPD, NRF2. Right part: ENCODE-based enriched histone PTMs on DEGs from IS_IGH_NGH (top) and IR_IGH_NGH (bottom).