. 2018 Oct 27;4(4):119. doi: 10.3390/jof4040119

Table 1.

Protein structures of yeast adhesins deposited in the Protein Data Bank (PDB, www.rcsb.org).

Micro-Organism	Adhesin	Ligand in the Structure	Mutations	PDB Code	Interacting Substrate/Function Properties	Refs
C. albicans	NT-Als3p (residues1-313)	Heptathreonine	-	4LEB	Endothelial and epithelial cells; fibronectin, laminin, type-IV collagen; abiotic surfaces (glass, plastics)	[62]
		Apo	K59M, A116V, Y301F	4LEE		[62]
	NT-Als3p (residues 1-299)	Apo	-	4LE8		*
	NT-Als9-2p	Apo	-	2Y7N		[63]
		Apo	G299W	2Y7O, 2YLH
		Fg-γ ¹	-	2Y7L
C. glabrata	N-Epa1p	Gal	-	4A3X	Epithelial cells, fibronectin, mucin	[43]
		Galβ-1,3-Glc	-	4AF9		[44]
		Galβ-1,3-Glc	E227D, Y228N	4AFC		[44]
		Galβ-1,3-GalNAc (T antigen)	-	4ASL		[44]
				4D3W		[52]
		Galβ-1,4-Glc (lactose)		4COU		[52]
		Glycerol	E227D, Y228N, D229N	4AFA		[44]
		Glycerol	R226I, E227G, Y228K	4AFB		[44]
	N-Epa6p	Galβ-1,4-Glc (lactose)		4COU		[52]
		Galβ-1,3-GalNAc (T-antigen)		4COW		[52]
		N-acetyl-D-lactosamine		4COY		[52]
		Lacto-N-biose		4COZ		[52]
		α1-3-galactobiose		4COV		[52]
	N-Epa9p	Galβ-1,4-Glc	-	4CP0		*
		Galβ-1,3-GlcNAc	-	4CP1		*
		Galβ-1,4-GlcNAc	-	4CP2		*
S. cerevisiae	N-Flo1p	Apo	-	4LHL	Cell-cell interaction via cell surface mannans	[39]
		Man	-	4LHK	Cell-cell interaction via cell surface mannans	[39]
	N-Lg-Flo1p	Apo	-	4GQ7	Cell-cell interaction via cell surface mannans and phosphomannans	[5]
		Manα-1,2-Man	-	4LHK		[39]
	N-Lg-Flo5p	Apo	-	2XJQ	Cell-cell interaction via cell surface mannans	[6]
		Man	-	2XJP		[6]
		Man₃(D1)	-	2XJT		[6]
		Man₅(D2-3)	-	2XJR		[6]
		Manα-1,2-Man	-	2XJS		[6]
		Manα-1,2-Man	S277A	2XJU		[6]
		Glc	-	2XJV		[6]
	N-Flo11p	Apo	-	4UYR	Cell-cell and cell-hydrophobic plastic adhesion via hydrophobic interactions	[64]
			-	4UYS		[64]
			-	4UYT		[64]

¹ C-terminal end of human fibrinogen γ (Fg-γ): NH₃-GEGQQHHLGGAKQAGDV-CO₂. * Deposited in PDB but not yet published.