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. 2018 Oct 9;18:15–24. doi: 10.1016/j.molmet.2018.10.003

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Loss of Ago2 improves glucose homeostasis during insulin resistance. A, Western blotting analysis of Ago2 and Ago1 from liver of 14-week-old ob/Ago2^Alb mice and control Lep^ob/ob littermates (n = 3). B, Body weight in male ob/Ago2^Alb mice (n = 6) and control Lep^ob/ob littermates (n = 9) from 4 to 16 weeks of age. C, Body composition in 10-week-old ob/Ago2^Alb mice (n = 3) and control Lep^ob/ob littermates (n = 3). D, Random and fasting glucose measurements in 14-week-old ob/Ago2^Alb mice (n = 4) and control Lep^ob/ob littermates (n = 6). E, Random and fasting plasma insulin measurements in 14-week-old ob/Ago2^Alb mice (n = 4) and control Lep^ob/ob littermates (n = 6). F, Random glucose measurements from 4-8-weeks old ob/Ago2^Alb mice (n = 6) and control Lep^ob/ob littermates (n = 3). G, Glucose measurements during a glucose tolerance test on 14-week old ob/Ago2^Alb mice (n = 3) and control Lep^ob/ob littermates (n = 3). H, Glucose measurements during an insulin tolerance test on 15-week old ob/Ago2^Alb mice (n = 3) and control Lep^ob/ob littermates (n = 3). I, Western blotting analysis of G6pase and Gck from liver of 14-week-old ob/Ago2^Alb mice and control Lep^ob/ob littermates after overnight fasting (n = 3). J, Western blotting analysis of phosphorylated Akt2 at Ser473 (p-Akt2) and Akt2 from liver of 14-week-old ob/Ago2^Alb mice (n = 3) and control Lep^ob/ob littermates after overnight fasting (n = 3). K, Western blotting analysis of phosphorylated FoxO1 at Thr24 (p-FoxO1), FoxO1 and Pten from liver of 14-week-old ob/Ago2^Alb mice and control Lep^ob/ob littermates after overnight fasting (n = 3). L, qRT-PCR analysis of miR-148a from liver of 14-week-old ob/Ago2^Alb mice and control Lep^ob/ob littermates (n = 6). M, Western blotting analysis of Ago2, AMPKα and phosphorylated AMPKα (p-AMPKα at Thr172) from liver of 14-week-old ob/Ago2^Alb mice and control Lep^ob/ob littermates after overnight fasting (n = 3). N, Western blotting analysis of phosphorylated acetyl-CoA carboxylase at Ser79 (p-ACC), ACC and fatty acid synthase (FAS) from liver of 14-week-old ob/Ago2^Alb mice and control Lep^ob/ob littermates after overnight fasting (n = 3). O, Liver triglyceride content of 20-week-old ob/Ago2^Alb mice (n = 4) and control Lep^ob/ob littermates (n = 6). P, Quantitative real-time PCR analysis of lipid metabolism genes from liver tissue of 14-week-old ob/Ago2^Alb mice after overnight fasting (n = 6) and control Lep^ob/ob littermates (n = 6). Results are presented as mean ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001.