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Anatomical features of CAR constructs. CAR: chimeric antigen receptor; VH: variable heavy chain; VL: variable light chain; ZAP70: zeta-chain-associated protein kinase 70; LAT: linker for activation of T cells; scFv: single-chain variable fragment; TCR: T-cell receptor; CD: cluster of differentiation; SUPRA: split, universal, and programmable.
