Figure 3.

Islet and peri-islet exocrine vessels in control donors and donors with type 1 diabetes. Sections were stained and image analysis performed as described in section “Materials and Methods” for 16 control donors (N=10 islets/donor) and 17 donors with type 1 diabetes (N=7–20 islets/donor). Islet vessel diameters were significantly larger than peri-islet exocrine vessel diameters in control donors (A, ***p<0.001). Islet vessel density was significantly decreased compared with peri-islet exocrine vessel density in control islets (B, ***p<0.001). Islet and peri-islet exocrine vessel diameter and density were not significantly different in donors with type 1 diabetes (C–D, p>0.05). Scale bar = 100 µm.