Table 2.

Comparison of K-fold cross-validation performance for three GDSC drug sensitivity prediction approaches – Mapped Prediction (MP), CCLE model Prediction (CP) and Direct Prediction (DP) using data from CCLE

Drug	Pearson Correlation			NRMSE
	MP	CP	DP	MP	CP	DP
17-AAG	0.6062	0.4354	0.4591	0.2112	0.3073	0.2164
AZD6244	0.4692	0.3580	0.3579	0.1683	0.2173	0.1743
Nilotinib	0.8698	0.7957	0.4524	0.1093	0.1323	0.1242
Nutlin-3	0.5606	0.3102	0.5114	0.1852	0.2180	0.1808
PD-0325901	0.6132	0.5731	0.4224	0.1689	0.1875	0.1865
PD-0332991	0.0923	0.0305	0.0802	0.1748	0.1764	0.1755
PLX4720	0.6335	0.6135	0.5001	0.1242	0.159	0.1291

Bold values indicate the best performance