Figure 5.

Dlx5/6 GRKD mice gain less weight than controls and female Dlx5/6 GRKD mice have higher peak Corticosterone (Cort) release to acute restraint. (A) Female Dlx5/6 GRKD mice showed a significant interaction between genotype and week in cohort 1, but no individual week was significantly different in post hoc analysis. Cohort 2 females only had a significant effect of time. (B) Male Dlx5/6 GRKD mice weighed less than the controls throughout the study. ^#p ≤ 0.05 interaction; *p ≤ 0.05 post hoc. (C) Female mice showed an interaction between genotype and time during the acute restraint challenge. Post hoc analysis revealed cort was significantly higher for Female Dlx5/6 GRKD mice at the 30 min point (release point from restraint). (D) Male mice showed no differences in Cort throughout and after the restraint. ^#p ≤ 0.05 interaction; *p ≤ 0.05 post hoc.